CD532
CD532 is a potent and selective Aurora A kinase inhibitor (IC50 = 45 nM) that induces a conformational change in the kinase, leading to MYCN degradation. It is a valuable chemical probe for studying cancers, particularly neuroblastoma, in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1639009-81-6
Product Name Alternative
AuroraKinase, Aurora Kinase, Aurora A, 1 [4 ({4 [ (5 cyclopentyl 1H pyrazol 3 yl) imino] 1,4 dihydropyrimidin 2 yl}amino) phenyl] 3 [3 (trifluoromethyl) phenyl]urea, 1[4 ({4[ (5cyclopentyl1Hpyrazol3yl) imino]1,4dihydropyrimidin2yl}amino) phenyl]3[3 (trifluoromethyl) phenyl]urea, CD 532, CD532, CD-532
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation
Purity
99.49% (May vary between batches)
Solubility
DMSO:200 mg/mL (382.76 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.57 mM)
Smiles
N (C=1C=C (NN1) C2CCCC2) C3=NC (NC4=CC=C (NC (NC5=CC (C (F) (F) F) =CC=C5) =O) C=C4) =NC=C3
Molecular Formula
C26H25F3N8O
Molecular Weight
522.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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