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Imidazole ketone erastin

Imidazole ketone erastin (IKE) is a small molecule ferroptosis inducer that inhibits the system Xc- transporter, leading to cystine deprivation, glutathione depletion, and lethal lipid peroxidation. It is widely used in vitro and in vivo to investigate ferroptosis mechanisms and evaluate antitumor strategies in cancer research.

Product Specifications

CAS Number

1801530-11-9

Product Name Alternative

Ferroptosis, IKE, Imidazole ketone erastin

Field of Research

Cell Biology

Purity

98.48% (May vary between batches)

Solubility

DMSO:100 mg/mL (152.64 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.11 mM)

Smiles

CC (C) Oc1ccc (cc1-n1c (CN2CCN (CC2) C (=O) COc2ccc (Cl) cc2) nc2ccccc2c1=O) C (=O) Cn1ccnc1

Molecular Formula

C35H35ClN6O5

Molecular Weight

655.14

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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