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NSC 694621

NSC 694621 is a covalent inhibitor targeting the PCAF histone acetyltransferase at Cys574, leading to irreversible inactivation. It demonstrates anti-proliferative effects in SK-N-SH and HCT116 cell lines, supporting its investigation as a potential chemical probe for oncology research involving epigenetic mechanisms.

Product Specifications

CAS Number

104857-29-6

Product Name Alternative

NSC 694621, NSC694621, NSC-694621, Isothiazolo[5,4 b]pyridin 3 (2H) one, 2 (4 methoxyphenyl), Isothiazolo[5,4b]pyridin3 (2H) one, 2 (4methoxyphenyl)

Field of Research

Epigenetics & Chromatin, Neuroscience

Purity

99.70% (May vary between batches)

Solubility

DMSO:1 mg/mL (3.87 mM)

Smiles

O=C1C2=CC=CN=C2SN1C3=CC=C (OC) C=C3

Molecular Formula

C13H10N2O2S

Molecular Weight

258.3

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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