NSC 694621
NSC 694621 is a covalent inhibitor targeting the PCAF histone acetyltransferase at Cys574, leading to irreversible inactivation. It demonstrates anti-proliferative effects in SK-N-SH and HCT116 cell lines, supporting its investigation as a potential chemical probe for oncology research involving epigenetic mechanisms.
Product Specifications
CAS Number
104857-29-6
Product Name Alternative
NSC 694621, NSC694621, NSC-694621, Isothiazolo[5,4 b]pyridin 3 (2H) one, 2 (4 methoxyphenyl), Isothiazolo[5,4b]pyridin3 (2H) one, 2 (4methoxyphenyl)
Field of Research
Epigenetics & Chromatin, Neuroscience
Purity
99.70% (May vary between batches)
Solubility
DMSO:1 mg/mL (3.87 mM)
Smiles
O=C1C2=CC=CN=C2SN1C3=CC=C (OC) C=C3
Molecular Formula
C13H10N2O2S
Molecular Weight
258.3
Storage Conditions
-20°C
Notes
For research use only.
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