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N-[2- (5-Chloro-1H-indol-3-yl) ethyl]-4'-cyanobiphenyl-2-carboxaMide

This small molecule inhibitor of TAU cytotoxicity reduces lactate dehydrogenase (LDH) release in M17-TAU P301L cells with an EC50 of 325 nM. It serves as a useful research tool for investigating tau-mediated neurotoxicity in cellular models of tauopathies, such as Alzheimer's disease.

Product Specifications

CAS Number

1383373-65-6

Product Name Alternative

N[2 (5Chloro1Hindol3yl) ethyl]4'cyanobiphenyl2carboxaMide, Microtubule Associated, MicrotubuleAssociated, N [2 (5 Chloro 1H indol 3 yl) ethyl] 4' cyanobiphenyl 2 carboxaMide, tau

Field of Research

Signal Transduction

Purity

98.65% (May vary between batches)

Solubility

DMSO:55 mg/mL (137.54 mM)

Smiles

C (CNC (=O) C1=C (C=CC=C1) C2=CC=C (C#N) C=C2) C=3C=4C (NC3) =CC=C (Cl) C4

Molecular Formula

C24H18ClN3O

Molecular Weight

399.87

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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