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USP8-IN-1

USP8-IN-1 is a small molecule inhibitor of the deubiquitinase USP8, exhibiting an IC50 of 1.9 μM. It demonstrates anti-proliferative activity in cellular assays, such as in H1975 lung cancer cells with a GI50 of 82.04 μM. This compound is a useful research tool for studying USP8's role in oncology and EGFR signaling pathways.

Product Specifications

CAS Number

2477650-96-5

Product Name Alternative

USP8, USP8-IN-1, USP8inhibitor

Field of Research

Cell Biology, Molecular Biology, Protein Biochemistry

Purity

98.01% (May vary between batches)

Solubility

DMSO:112.5 mg/mL (290.35 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.32 mM)

Smiles

COc1ccc (N2CCN (CC2) C (=S) Nc2ccc (cc2) [N+] ([O-]) =O) c (N) c1

Molecular Formula

C18H21N5O3S

Molecular Weight

387.46

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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