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RP-6685

RP-6685 is a potent, selective, and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 of 5.8 nM. It demonstrates robust antitumor activity in mouse xenograft models, making it a valuable tool for investigating Polθ's role in DNA repair and oncology research, both in vitro and in vivo.

Product Specifications

CAS Number

2832047-80-8

Product Name Alternative

RP 6685, RP6685, RP-6685, RNA Synthesis, RNASynthesis, DNASynthesis, DNA polymerase, DNA Synthesis

Field of Research

Cell Biology, Molecular Biology

Purity

98.34% (May vary between batches)

Solubility

10% DMSO+90% Corn Oil:3.3 mg/mL (6.63 mM) ; DMSO:112.5 mg/mL (226.19 mM)

Smiles

Nc1ccc (nn1) C#CCN (C (=O) Cc1ncc (cc1C (F) (F) F) C (F) (F) F) c1ccc (F) cc1

Molecular Formula

C22H14F7N5O

Molecular Weight

497.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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