UAMC-3203 hydrochloride
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM[1].
Product Specifications
CAS Number
2271358-65-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/uamc-3203-hydrochloride.html
Concentration
10mM
Purity
98.82
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O.Cl
Molecular Formula
C25H38ClN5O2S
Molecular Weight
508.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61 (22) :10126-10140.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Acta Neuropathol Commun. 2023 Jul 25;11 (1) :121.|Acta Neuropathol. 2024 Jun 22;147 (1) :106.|Bioorg Chem. 2024 Jun:147:107412.|Cell Biol Toxicol. 2022 Jun;38 (3) :505-530.|Res Sq. 2024 Jul 09.|Research Square Print. October 26th, 2022.|Cell Death Differ. 2025 Oct 7.|J Neurochem. 2025 Oct;169 (10) :e70246.|Nat Cell Biol. 2025 Aug;27 (8) :1288-1300.|Sci Rep. 2024 Aug 30;14 (1) :20180.
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