VU0420373

VU0420373 is a potent small molecule activator of the Staphylococcus aureus HssRS heme sensor system (EC50 = 10.7 μM) . It induces bacterial heme biosynthesis and demonstrates toxicity against fermenting S. aureus, making it a useful research tool for studying heme-dependent regulation and antimicrobial strategies in both in vitro and in vivo models.