BTX161
BTX161 is a thalidomide-based analog and potent degrader of CKIα, demonstrating superior activity to lenalidomide in human AML cell models. It induces DNA damage response and p53 activation while paradoxically stabilizing MDM2, making it a valuable chemical probe for studying p53 pathway dynamics in oncology research.
Product Specifications
CAS Number
2052301-24-1
Field of Research
Metabolism Research, Stem Cell & Developmental Biology
Smiles
Cc1cccc2C (=O) N (Cc12) [C@H]1CCCC (=O) NC1=O
Molecular Formula
C15H16N2O3
Molecular Weight
272.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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