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BTX161

BTX161 is a thalidomide-based analog and potent degrader of CKIα, demonstrating superior activity to lenalidomide in human AML cell models. It induces DNA damage response and p53 activation while paradoxically stabilizing MDM2, making it a valuable chemical probe for studying p53 pathway dynamics in oncology research.

Product Specifications

CAS Number

2052301-24-1

Field of Research

Metabolism Research, Stem Cell & Developmental Biology

Smiles

Cc1cccc2C (=O) N (Cc12) [C@H]1CCCC (=O) NC1=O

Molecular Formula

C15H16N2O3

Molecular Weight

272.3

Storage Conditions

-20°C

Notes

For research use only.

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