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MK-5108

MK-5108 (VX-689) is a highly selective, sub-nanomolar inhibitor of Aurora-A kinase (IC50 = 0.064 nM) . It is widely used in cancer research to study mitotic progression and has demonstrated antitumor activity in both cellular assays and in vivo xenograft models.

Product Specifications

CAS Number

1010085-13-8

Product Name Alternative

Inhibit, MK 5108, MK5108, MK-5108, Inhibitor, Autophagy, AuroraKinase, Aurora A, Aurora Kinase, VX 689, VX689, VX-689

Field of Research

Cell Biology, Epigenetics & Chromatin

Purity

98.76% (May vary between batches)

Solubility

DMSO:50 mg/mL (108.24 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.33 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

OC (=O) [C@@]1 (Cc2cccc (Nc3nccs3) n2) CC[C@@H] (CC1) Oc1cccc (Cl) c1F

Molecular Formula

C22H21ClFN3O3S

Molecular Weight

461.94

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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