SDI-118
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC50 of 13 nM[1].
Product Specifications
CAS Number
1651179-19-9
UNSPSC
12352005
Target
Synaptic Vesicle Proteins
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sdi-118.html
Purity
98.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C[C@H](C2=CC(F)=C(C(F)=C2)F)CN1CN3C(Cl)=NC=N3
Molecular Formula
C13H10ClF3N4O
Molecular Weight
330.69
References & Citations
[1]Botermans W, et al., SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement. Front Pharmacol. 2023 Jan 17;13:1066447.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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