D-69491 (hydrochloride)

D-69491 hydrochloride is a HER-2 tyrosine kinase inhibitor that reduces HER-2 phosphorylation, inhibits the proliferation of SKOV-3 cells, and has anticancer activity[1].

Product Specifications

CAS Number

[346599-65-3]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/d-69491-hydrochloride.html

Smiles

O=C(C1=CC(C)=C(/C=C(C2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2N4)\C4=O)N1)NCCN5CCOCC5.Cl

Molecular Formula

C25H26Cl2FN7O3

Molecular Weight

562.42

References & Citations

[1]Shaker Abuharbeid, et al. Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371 (2) :141-51.