D-69491 (hydrochloride)
Product Specifications
UNSPSC Description
D-69491 hydrochloride is a HER-2 tyrosine kinase inhibitor that reduces HER-2 phosphorylation, inhibits the proliferation of SKOV-3 cells, and has anticancer activity[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-69491-hydrochloride.html
Smiles
O=C(C1=CC(C)=C(/C=C(C2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2N4)\C4=O)N1)NCCN5CCOCC5.Cl
Molecular Weight
562.42
References & Citations
[1]Shaker Abuharbeid, et al. Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371(2):141-51.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-135725/D-69491-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-135725/
Clinical Information
No Development Reported
CAS Number
346599-65-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
