Verosudil
Verosudil (AR-12286) is a potent ROCK inhibitor with Ki values of 2 nM for both ROCK1 and ROCK2. It lowers intraocular pressure by enhancing trabecular meshwork outflow, as demonstrated in steroid-induced ocular hypertension models in mice, supporting research in glaucoma pathophysiology.
Product Specifications
CAS Number
1414854-42-4
Product Name Alternative
AR 12286, AR12286, AR-12286, ROCK1, ROCK2, Verosudil
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.68% (May vary between batches)
Solubility
DMSO:45 mg/mL (137.45 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.05 mM)
Smiles
CN (C) C (C (=O) Nc1ccc2c (cc[nH]c2=O) c1) c1ccsc1
Molecular Formula
C17H17N3O2S
Molecular Weight
327.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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