PDE4-IN-9

PDE4-IN-9 (Compound 5j) is a potent PDE4 inhibitor with an in vitro IC50 of 1.4 μM, demonstrating superior enzymatic inhibition to rolipram. It exhibits significant in vivo efficacy in LPS-induced models of asthma, COPD, and sepsis, supporting its research utility in inflammatory and pulmonary disease studies.