DL-threo-PDMP (hydrochloride)

DL-threo-PDMP hydrochloride is the hydrochloride form of DL-threo-PDMP that is a competitive glucosylceramide synthase (GCS) inhibitor. DL-threo-PDMP resensitizes refractory testicular germ cell tumors and epithelial ovarian cancer orthoxenografts to cisplatin in mice[1].

Product Specifications

CAS Number

[80938-69-8]

Product Name Alternative

4'-Fluoro-5'-O-sulfamoyladenosine; NSC 521007

UNSPSC

12352005

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dl-threo-pdmp-hydrochloride.html

Purity

99.40

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.Cl

Molecular Formula

C23H39ClN2O3

Molecular Weight

427.02

References & Citations

[1]Piulats JM, et al. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018 Aug 1;24 (15) :3755-3766.