VAS2870
VAS2870 is a NADPH oxidase (NOX) inhibitor.
Product Specifications
CAS Number
722456-31-7
UNSPSC
12352005
Hazard Statement
H302
Target
NADPH Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/VAS2870.html
Purity
98.79
Solubility
DMSO : 83.3 mg/mL (ultrasonic)
Smiles
C1(N(CC2=CC=CC=C2)N=N3)=C3C(SC4=NC5=C(C=CC=C5)O4)=NC=N1
Molecular Formula
C18H12N6OS
Molecular Weight
360.39
Precautions
H302
References & Citations
[1]ten Freyhaus H, et al. Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation. Cardiovasc Res. 2006 Jul 15;71 (2) :331-41.|[2]Sancho P, et al. The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells. Biochem Pharmacol. 2011 Apr 1;81 (7) :917-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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