17β-HSD1-IN-1

17β-HSD1-IN-1 (Compound 1) is a potent and highly selective inhibitor of 17β-HSD1, demonstrating an IC50 of 5.6 nM for this enzyme versus 3155 nM for 17β-HSD2. This small molecule is a valuable research tool for investigating the role of estrogen metabolism in non-small cell lung cancer (NSCLC) models, both in vitro and in vivo.