Fraxetin

Fraxetin is isolated from Fraxinus rhynchophylla Hance and has oral bioactivity. Fraxetin has anti-tumor, antibacterial, antioxidant, and anti-inflammatory effects. Fraxetin can induce cell apoptosis[1][2][3].

Product Specifications

CAS Number

[574-84-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fraxetin.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC(OC)=C(O)C(O)=C2O1

Molecular Formula

C10H8O5

Molecular Weight

208.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104.|[2]Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14 (6) :7374-7378.|[3]Haiting Wang, et al. Antibacterial mechanism of fraxetin against Staphylococcus aureus. Mol Med Rep. 2014 Nov;10 (5) :2341-5.