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RUNX1/ETO tetramerization-IN-1

RUNX1/ETO tetramerization-IN-1 is a potent small-molecule inhibitor that disrupts the NHR2-mediated tetramerization of the RUNX1/ETO oncoprotein (EC50 = 0.25 μM) . It restores downregulated gene expression, inhibits RUNX1/ETO-dependent leukemia cell proliferation in vitro, and demonstrates significant anti-tumor efficacy in mouse models of AML.

Product Specifications

CAS Number

88755-39-9

Field of Research

Cancer Biology

Smiles

C (CC (=O) C=1C=C2C (=CC1) OCO2) (C (O) =O) C=3C=C4C (=CC3) OCO4

Molecular Formula

C18H14O7

Molecular Weight

342.3

Storage Conditions

-20°C

Notes

For research use only.

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