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UCB-5307

UCB-5307 is a small molecule inhibitor of TNFR1 signaling that binds human TNFα with high affinity (K_D ~6-9 nM) via slow kinetics and can disrupt pre-formed TNF/TNFR1 complexes. Its utility in exploring TNF-driven pathology makes it a valuable tool for in vitro and in vivo inflammatory disease research.

Product Specifications

CAS Number

1515887-44-1

Product Name Alternative

TNF-α

Field of Research

Cell Biology

Purity

98.02% (May vary between batches)

Solubility

DMSO:65 mg/mL (189.27 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.82 mM)

Smiles

Cc1ccc (C) c (Cn2c (nc3ccccc23) C (O) c2ccncc2) c1

Molecular Formula

C22H21N3O

Molecular Weight

343.42

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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