HCAII-IN-3

HCAII-IN-3 (Compound 16) is a potent small molecule inhibitor targeting human carbonic anhydrase isoforms I, II, IX, and XII with Ki values of 403.8 nM, 5.1 nM, 10.2 nM, and 5.2 nM, respectively. Its high affinity, particularly for the tumor-associated hCA IX and XII, supports its application in anticancer research, as evidenced by related compounds demonstrating activity in vitro.