c-erbB2 (HER-2, neu Receptor)

May be stored at 4 °C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at-20 °C or colder. Aliquots are stable for at least 12 months at-20 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Reacts with the intact cells,1,2 slightly increases (~2-fold) the tyrosine kinase activity,1 accelerates (~50%) c-erbB-2 turnover,1 and inhibits (~80%) tumorigenic growth in CD1/nude mice of N87 human gastric carcinoma cell line overexpressing c-erbB-2.1 Species Crossreactivity: human. Does not react with mouse and rat.