JG-23
JG-23 is a 4-chloro modified analog with ability to promote t-tau degradation. JG-23 exhibits good metabolic stability with a long T1/2 value (36 min) in mouse liver microsome assays[1].
Product Specifications
CAS Number
2640819-75-4
UNSPSC
12352005
Target
Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jg-23.html
Purity
99.64
Solubility
DMSO : 4.55 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
CN1/C(SC2=CC=C(Cl)C=C21)=C3C(N(/C(S/3)=C/C4=CC=NC=C4)CC)=O
Molecular Formula
C19H16ClN3OS2
Molecular Weight
401.93
References & Citations
[1]Shao H, et al. Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels. Bioorg Med Chem Lett. 2021 Jun 1;41:128025.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH031278 100 µg
Recombinant Human TrkA/NTRK1 Protein (aa 194-413, His Tag)
Sign In for Pricing
View Details 
HA723775 100 µL
Non-muscle Myosin IIB / MYH10 Recombinant Rabbit monoclonal Antibody
Sign In for Pricing
View Details 
