Vutiglabridin
Vutiglabridin (HSG4112) is a novel, brain-penetrant racemic modulator of mitochondrial paraoxonase 2 (PON2) . This optimized Glabridin analogue shows efficacy in preclinical models, ameliorating MPTP-induced neurodegeneration in Parkinson's disease mice and MPP+-induced cytotoxicity in SH-SY5Y cells. It is also in clinical Phase 2 trials for obesity.
Product Specifications
CAS Number
1800188-47-9
Product Name Alternative
HSG 4112, HSG4112, HSG-4112, LMPTP, PON2, Vutiglabridin
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology
Purity
97.35% (May vary between batches)
Solubility
DMSO:10 mg/mL (28.21 mM)
Smiles
CC1 (C) OC2=C (C3=C (CC (CO3) C4=C (O) C=C (OCC) C=C4) C=C2) CC1
Molecular Formula
C22H26O4
Molecular Weight
354.44
Storage Conditions
-20°C
Notes
For research use only.
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