Chromenone 1
Chromenone 1 is a small molecule that potently enhances osteogenic BMP signaling by inducing a kinase-independent negative feedback loop on TGFβ, thereby amplifying nuclear BMP-Smad activity. This mechanism supports its use in vitro and in vivo for bone regeneration research and studying TGFβ/BMP pathway crosstalk.
Product Specifications
CAS Number
1639929-29-5
Product Name Alternative
Bone morphogenetic protein (BMP), Smad, TGFbeta/Smad, TGFbeta, TGF-beta, TGF-β/Smad, TGFβ, TGF-b/Smad, TGFb
Field of Research
Stem Cell & Developmental Biology
Purity
99.81% (May vary between batches)
Solubility
DMSO:50 mg/mL (139.94 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.6 mM)
Smiles
O=C1C (=C (OC=2C1=CC=CC2) N3C=NC=N3) C4=CC=C (C (F) (F) F) C=C4
Molecular Formula
C18H10F3N3O2
Molecular Weight
357.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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