D18
D18 is a dual TLR7/8 agonist (EC50: 24 nM hTLR7, 10 nM hTLR8) that epigenetically upregulates PD-L1 to potentiate anti-PD-1/PD-L1 therapy. It also serves as a cytotoxic payload for antibody-drug conjugates (ADCs), such as HE-S2, supporting research in immuno-oncology and ADC development [1].
Product Specifications
CAS Number
2230218-36-5
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
N (CCCC) C=1C2=C (C=CC (CC3=CC=C (CN (C) C) C=C3) =N2) N=C (N) N1
Molecular Formula
C21H28N6
Molecular Weight
364.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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