DCeMM2
DCeMM2 is a molecular glue degrader that induces the interaction of CDK12-cyclin K with the CRL4B E3 ligase, resulting in the ubiquitination and proteasomal degradation of cyclin K. This mechanism enables the study of transcription and DNA damage response pathways in both cellular and in vivo research models.
Product Specifications
CAS Number
296771-07-8
Product Name Alternative
MolecularGlues, Molecular Glues
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.68% (May vary between batches)
Solubility
DMSO:16.7 mg/mL (45.04 mM) ;10% DMSO+90% Corn Oil:1.5 mg/mL (4.05 mM)
Smiles
Clc1ccc (NC (=O) CSc2nnc3c (n2) [nH]c2ccccc32) nc1
Molecular Formula
C16H11ClN6OS
Molecular Weight
370.82
Storage Conditions
-20°C
Notes
For research use only.
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