PKC-IN-4

PKC-IN-4 (compound 7l) is a potent, orally bioavailable inhibitor of atypical PKC (IC50 = 0.52 μM) . It suppresses TNF-α-induced NF-κB activity in vitro and reduces VEGF/TNFα-mediated retinal vascular permeability, supporting research in oncology, inflammation, and diabetic retinopathy.