TLR4-IN-C34-C2-COOH
Product Specifications
UNSPSC Description
TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
Target Antigen
PROTAC Linkers; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation;PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr4-in-c34-c2-cooh.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCO[C@H]1[C@H](NC(C)=O)[C@H]([C@H]([C@@H](COC(C)=O)O1)OC(C)=O)OC(C)=O
Molecular Weight
447.43
References & Citations
[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. Published 2013 Jun 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W092043/TLR4-IN-C34-C2-COOH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W092043/TLR4-IN-C34-C2-COOH-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1159408-54-4
Available Sizes
Curated Selection
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