PARP-1-IN-1

PARP-1-IN-1 is a potent and selective PARP-1 inhibitor with sub-nanomolar activity (IC50 = 0.96 nM) . It is orally bioavailable and has shown significant in vivo efficacy in xenograft models like MDA-MB-436, making it a valuable chemical probe for studying DNA damage response and oncology research.