ATR-IN-14
ATR-IN-14 (compound 1) is a potent and selective ATR kinase inhibitor, achieving 98.03% inhibition of ATR signaling at 25 nM and an IC50 of 64 nM in LoVo colorectal cancer cells. This small molecule is a valuable chemical probe for studying DNA damage response pathways in oncology research, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
2765785-88-2
Field of Research
Epigenetics & Chromatin, Molecular Biology, Signal Transduction
Smiles
FC=1C2=C (C (=NC1) C=3C=CNN3) N=C (C=C2C=4N (C) N=CC4) N5[C@H] (C) COCC5
Molecular Formula
C20H20FN7O
Molecular Weight
393.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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