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DC-LC3in-D5

DC-LC3in-D5 is a potent, selective covalent inhibitor of LC3A/B that targets Lys49 on LC3B with an IC50 of 200 nM. It disrupts autophagy by blocking LC3B lipidation, leading to p62 accumulation and reduced autophagosome formation. This inhibitor is a valuable chemical tool for studying autophagy mechanisms in both cellular and in vivo research models.

Product Specifications

CAS Number

2868312-73-4

Field of Research

Cell Biology

Purity

99.79% (May vary between batches)

Solubility

DMSO:30 mg/mL (75.51 mM)

Smiles

O=C1C (=CNCCN2CCOCC2) C (=O) CC (C=3C=CC=C (Cl) C3Cl) C1

Molecular Formula

C19H22Cl2N2O3

Molecular Weight

397.3

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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