DC-LC3in-D5
DC-LC3in-D5 is a potent, selective covalent inhibitor of LC3A/B that targets Lys49 on LC3B with an IC50 of 200 nM. It disrupts autophagy by blocking LC3B lipidation, leading to p62 accumulation and reduced autophagosome formation. This inhibitor is a valuable chemical tool for studying autophagy mechanisms in both cellular and in vivo research models.
Product Specifications
CAS Number
2868312-73-4
Field of Research
Cell Biology
Purity
99.79% (May vary between batches)
Solubility
DMSO:30 mg/mL (75.51 mM)
Smiles
O=C1C (=CNCCN2CCOCC2) C (=O) CC (C=3C=CC=C (Cl) C3Cl) C1
Molecular Formula
C19H22Cl2N2O3
Molecular Weight
397.3
Storage Conditions
-20°C
Notes
For research use only.
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