Trk-IN-10
Trk-IN-10 (Compound 14j) is a potent and selective TRK inhibitor, with sub-nanomolar activity against TrkA (IC50 = 0.86 nM) and its G595R mutant. Its selectivity profile over kinases like ALK supports its utility as a chemical probe for studying TRK-driven oncogenesis in both cellular and animal models of solid tumors.
Product Specifications
CAS Number
2700265-61-6
Field of Research
Signal Transduction
Smiles
C[C@H]1N2C=3C (=CN4C (N3) =C (C=N4) C (=O) NC[C@H] (C) OC=5C (C2) =CC=C (F) C5) OC1
Molecular Formula
C20H20FN5O3
Molecular Weight
397.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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