γ-Secretase modulator 12
Compound 1a is a γ-secretase modulator that selectively lowers Aβ42 levels (IC50 = 0.39 μM) for Alzheimer's disease research. It demonstrates suitable brain penetration in mice (Kp = 0.72), supporting its use in both in vitro biochemical assays and in vivo pharmacological studies.
Product Specifications
CAS Number
2204249-82-9
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
CC1=C (N2C (C (OCC3=CC=CC=C3) =CC=C2) =N1) C=4C=C5C (=CC4) C (=O) N (CC) C5
Molecular Formula
C25H23N3O2
Molecular Weight
397.47
Storage Conditions
-20°C
Notes
For research use only.
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