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SHP2-IN-8

SHP2-IN-8 is a potent, selective, and reversible allosteric inhibitor of SHP2 with an IC50 of 23 nM. It induces target thermal stabilization (ΔTm = 7.01°C) and demonstrates cellular activity by inhibiting AKT phosphorylation and promoting apoptosis in HeLa cells, useful for cancer signaling research.

Product Specifications

CAS Number

1801692-60-3

Field of Research

Cell Biology, Metabolism Research, Signal Transduction

Smiles

NC=1N=C (N2CCC (CN) (C) CC2) C=NC1SC3=C (Cl) C (Cl) =CC=C3

Molecular Formula

C17H21Cl2N5S

Molecular Weight

398.35

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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