SHP2-IN-8
SHP2-IN-8 is a potent, selective, and reversible allosteric inhibitor of SHP2 with an IC50 of 23 nM. It induces target thermal stabilization (ΔTm = 7.01°C) and demonstrates cellular activity by inhibiting AKT phosphorylation and promoting apoptosis in HeLa cells, useful for cancer signaling research.
Product Specifications
CAS Number
1801692-60-3
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Smiles
NC=1N=C (N2CCC (CN) (C) CC2) C=NC1SC3=C (Cl) C (Cl) =CC=C3
Molecular Formula
C17H21Cl2N5S
Molecular Weight
398.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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