PD-1/PD-L1-IN 6
PD-1/PD-L1-IN 6 (Compound A13) is a potent small molecule inhibitor of the PD-1/PD-L1 immune checkpoint, exhibiting an IC50 of 132.8 nM. It demonstrates significant immunoregulatory activity in vitro, restoring T-cell function and enhancing interferon-γ secretion in co-culture models without significant cytotoxicity, supporting its use in immuno-oncology research.
Product Specifications
CAS Number
2393983-76-9
Field of Research
Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation
Smiles
C (=O) (N1C=2C (=C (C=CC2) C3=CC=CC=C3) CC1) C4=CC (OC) =C (CNCCO) C=C4
Molecular Formula
C25H26N2O3
Molecular Weight
402.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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