Pan-HER-IN-1
Pan-HER-IN-1 (Compound C5) is an orally bioavailable, irreversible pan-HER inhibitor with low nanomolar potency against EGFR, HER2, HER4, and mutant EGFR (T790M/L858R) . It induces apoptosis and demonstrates antitumor efficacy in both cellular assays and in vivo research models, making it a useful tool for studying oncogenic HER signaling pathways.
Product Specifications
CAS Number
1639040-94-0
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C=1C2=C (C=CC (NC (C=C) =O) =C2) N=CN1) C=3C=C4C (=CC3) NC=C4Br
Molecular Formula
C19H14BrN5O
Molecular Weight
408.25
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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