Mt KARI-IN-5
Mt KARI-IN-5 (compound 6c) is a potent and selective inhibitor of Mycobacterium tuberculosis ketohydrin reductase I (MtbKARI), exhibiting an inhibitory constant (Ki) of 4.72 μM. It demonstrates potent antitubercular activity against Mtb H37Rv with a MIC of 1.56 μM and shows low cytotoxicity in HEK cells (IC50 >64 μg/mL) . This inhibitor is a valuable tool compound for studying MtbKARI function in tuberculosis drug discovery research, applicable in both enzymatic and whole-cell assays.
Product Specifications
CAS Number
2413974-69-1
Field of Research
Infectious Disease & Virology
Smiles
N (S (=O) (=O) C1=CC=C (C (C) =O) C=C1) C=2SC (=NN2) C=3SC (N (=O) =O) =CC3
Molecular Formula
C14H10N4O5S3
Molecular Weight
410.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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