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J-1063

J-1063 is a potent and selective oral inhibitor of ALK5 (IC50: 39 nM) . It demonstrates anti-fibrotic efficacy in liver fibrosis models by reducing inflammatory infiltration, collagen deposition, and hepatocyte necrosis, making it a valuable tool for in vitro and in vivo TGF-β signaling research.

Product Specifications

CAS Number

2374772-46-8

Field of Research

Stem Cell & Developmental Biology

Smiles

C (C (NC1=CC=CC=C1) =O) N2C=C (C (=N2) C=3N=C (C) C=CC3) C4=CC=5C (S4) =CC=NC5

Molecular Formula

C24H19N5OS

Molecular Weight

425.51

Storage Conditions

-20°C

Notes

For research use only.

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