PDHK-IN-4

PDHK-IN-4 (Compound 30) is a highly potent and selective inhibitor of pyruvate dehydrogenase kinase isoforms 2 and 4, with IC50 values in the low nanomolar range. This small molecule is a valuable research tool for investigating metabolic reprogramming in cancer models, both in vitro and in vivo, to explore therapeutic strategies targeting tumor metabolism.