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FLT3-IN-12

FLT3-IN-12 is a potent and orally bioavailable FLT3 inhibitor with high selectivity over c-KIT, demonstrating low nanomolar activity against FLT3-WT and FLT3-D835Y mutants. It exhibits strong anti-proliferative effects in FLT3-ITD-positive MV4-11 AML cells and has shown efficacy in preclinical in vivo models of acute myeloid leukemia.

Product Specifications

CAS Number

2499966-67-3

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

O=C1C=2C (=CC (NC=3N=C (N[C@@H]4CC[C@H] (N) CC4) C (C (F) (F) F) =CN3) =CC2) C=CN1C

Molecular Formula

C21H23F3N6O

Molecular Weight

432.44

Storage Conditions

-20°C

Notes

For research use only.

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