TYK2-IN-12

TYK2-IN-12 is a potent and selective TYK2 inhibitor with a Ki of 0.51 nM, demonstrating oral activity. It effectively blocks IL-12-induced IFNγ production in human and mouse whole blood assays, supporting its use as a research tool for investigating autoimmune conditions such as psoriasis in both in vitro and in vivo models.