TYK2-IN-12
TYK2-IN-12 is a potent and selective TYK2 inhibitor with a Ki of 0.51 nM, demonstrating oral activity. It effectively blocks IL-12-induced IFNγ production in human and mouse whole blood assays, supporting its use as a research tool for investigating autoimmune conditions such as psoriasis in both in vitro and in vivo models.
Product Specifications
CAS Number
2244061-66-1
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C1=C2C (=NC (=C1) C3=C (F) C=CC=C3F) CNC2=O) C4=CC=C (C (=O) N5CCCC5) C=C4
Molecular Formula
C24H20F2N4O2
Molecular Weight
434.44
Storage Conditions
-20°C
Notes
For research use only.
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