Zibotentan
Zibotentan (ZD4054) is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 21 nM, showing no affinity for the ETB receptor. This investigational compound has been evaluated in Phase 3 clinical trials, primarily for oncology research such as prostate cancer, and is used in vitro and in vivo to study endothelin-mediated pathways.
Product Specifications
CAS Number
186497-07-4
Product Name Alternative
Inhibitor, ET-A, ETA, EndothelinReceptor, Endothelin Receptor, inhibit, Apoptosis, anticancer, bcl-2, 44MAPK, caspase-3, CRPC, ZD4054, ZD-4054, ZD 4054, Zibotentan, p42
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
97.00% (May vary between batches)
Solubility
DMSO:23 mg/mL (54.19 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+90% Corn Oil:2 mg/mL (4.71 mM)
Smiles
COc1nc (C) cnc1NS (=O) (=O) c1cccnc1-c1ccc (cc1) -c1nnco1
Molecular Formula
C19H16N6O4S
Molecular Weight
424.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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