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Glucosylceramide synthase-IN-2

Glucosylceramide synthase-IN-2 (T-690) is a potent, orally bioavailable, and brain-penetrant inhibitor of glucosylceramide synthase, with IC50 values of 15 nM (human) and 190 nM (mouse) . It functions via non-competitive inhibition and is a valuable research tool for studying glycosphingolipid metabolism in both cellular and animal models of related diseases.

Product Specifications

CAS Number

2597958-02-4

Field of Research

Metabolism Research

Smiles

CC (C) (O) c1ccc (NC (=O) c2ccnn (-c3ccccc3OCC (F) (F) F) c2=O) cc1

Molecular Formula

C22H20F3N3O4

Molecular Weight

447.41

Storage Conditions

-20°C

Notes

For research use only.

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