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KRAS inhibitor-12

KRAS inhibitor-12 is a potent and selective KRAS G12C inhibitor with an IC50 of 0.537 μM. It effectively suppresses p-ERK signaling in cellular models such as MIA PaCa-2 and A549 cells, supporting its research utility in pancreatic, colorectal, and non-small cell lung cancer studies.

Product Specifications

CAS Number

2230874-00-5

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Smiles

FC=1C=2C (=C (SN2) N3CCN (C (C=C) =O) CC3) C=C (Cl) C1C4=C (Cl) C=CC (N) =N4

Molecular Formula

C19H16Cl2FN5OS

Molecular Weight

452.33

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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